Institut Pasteur and INFRAFRONTIER 2020 are organizing the meeting « Modeling microbial ecosystems of mammals : current tools and challenges », which aims to discuss advances on the modeling of microbiota ecosystems, animal models that allow to explore the role of the microbiota-host superorganism, the microbial humanization of animal models, models of microbiota-dependent pathogenesis, and their impact on diagnostic and therapeutic medicine. This meeting is planned for October 15th and 16th 2018 at the Institut Pasteur in Paris.